The Cs2CO3-Catalyzed Reaction of 2-Oxindoles with Enones for the Preparation of Indolin-3-Ones and Their Further Transformation

被引：19
|
作者：
Shao, Ying [1 ]
Zeng, Yu-Mei [1 ]
Ji, Jie-Ying [1 ]
Sun, Xiao-Qiang [1 ]
Yang, Hai-Tao [1 ]
Miao, Chun-Bao [1 ]
机构：
[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Adv Catalysis & Green Mfg Collaborat Innovat Ctr, Changzhou 213164, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 24期
基金：
美国国家科学基金会;
关键词：
CATALYZED INTRAMOLECULAR AMINATION; C-H AMINATION; INDOLE ALKALOIDS; SPIRO-PSEUDOINDOXYL; CASCADE; BONDS; (+)-ISATISINE; REARRANGEMENT; HYDROXYLATION; DERIVATIVES;
D O I：
10.1021/acs.joc.6b01993
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Cs2CO3-catalyzed reaction of 2-oxindoles with enones affords 2,2-disubstituted indolin-3-ones through domino "Michael addition-oxidation-ring-cleavage-C-N coupling" process. O-2 acts as the sole oxidant to accomplish the oxidative process. The indolin-3-ones can be further transformed to pyridazine, azirdine-fused 3-oxindoles, 4-quinolone derivatives easily.
引用
收藏
页码：12443 / 12450
页数：8
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