Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration

被引：26

作者：

Gupta, Kunal ^{[1
,2
,3
,4
]}

Chandran, Siddharthan ^{[3
]}

Hardingham, Giles E. ^{[4
]}

机构：

[1] Univ Cambridge, Dept Clin Neurosci, Anne McLaren Lab Regenerat Med, Cambridge CB2 0SZ, England

[2] Univ Cambridge, Dept Clin Neurosci, Cambridge Ctr Brain Repair, Cambridge CB2 0SZ, England

[3] Univ Edinburgh, MRC Ctr Regenerat Med, Euan MacDonald Ctr, Edinburgh EH16 4SB, Midlothian, Scotland

[4] Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2013年 / 75卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

antioxidants; astrocytes; neuroprotection; Nrf2; oxidative stress; stem cells; AMYOTROPHIC-LATERAL-SCLEROSIS; TRANSGENIC MOUSE MODEL; FRONTOTEMPORAL LOBAR DEGENERATION; EFFICIENT NEURAL CONVERSION; BETA-AMYLOID PEPTIDES; IN-VITRO; MOTOR-NEURONS; HUMAN ES; DOPAMINERGIC-NEURONS; PARKINSONS-DISEASE;

D O I：

10.1111/bcp.12022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glia, including astrocytes, are increasingly at the forefront of neurodegenerative research for their role in the modulation of neuronal function and survival. Improved understanding of underlying disease mechanisms, including the role of the cellular environment in neurodegeneration, is central to therapeutic development for these currently untreatable diseases. In these endeavours, experimental models that more closely reproduce the human condition have the potential to facilitate the transition between experimental studies in model organisms and patient trials. In this review we discuss the growing role of astrocytes in neurodegenerative diseases, and how astrocytes generated from human pluripotent stem cells represent a useful tool for analyzing astrocytic signalling and influence on neuronal function.

引用

页码：907 / 918

页数：12

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