Two photon photosensitizers for PDT: molecular engineering towards understanding of their excited state photophysics

被引：0

作者：

Lanoe, Pierre-Henri ^{[1
]}

Gallavardin, Thibault ^{[1
]}

Mettra, Bastien ^{[1
]}

Monnereau, Cyrille ^{[1
]}

Andraud, Chantal ^{[1
]}

机构：

[1] Univ Lyon 1, Chim Lab, CNRS, UMR 5182,Ecole Normale Super Lyon, F-69364 Lyon 07, France

来源：

OPTICAL MATERIALS AND BIOMATERIALS IN SECURITY AND DEFENCE SYSTEMS TECHNOLOGY IX | 2012年 / 8545卷

关键词：

Two-photon absorption; spectroscopy; singlet oxygen; chromophore engineering; photodynamic therapy; SINGLET OXYGEN; ABSORPTION; DESIGN;

D O I：

10.1117/12.2007265

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

We have recently initiated a research project that aims at understanding how systematic variations of the number and positioning of a given Inter-System Crossing (ISC) promoter (1,4-dibromophenyl) along the Intramolecular Charge Transfer (ICT) axis of chromophores will affect the outcome of singlet oxygen production, and how this effect will be related to the nature of the ICT transition. In this communication, this strategy is discussed and we show that a clear influence of the ISC promoter's position on the chromophore exists, which can be used both to improve the singlet oxygen generation efficiency of the sensitizer, but also its linear and nonlinear spectroscopic features.

引用

页数：7

共 24 条

[1] Design of organic molecules with large two-photon absorption cross sections [J].

Albota, M ;

Beljonne, D ;

Brédas, JL ;

Ehrlich, JE ;

Fu, JY ;

Heikal, AA ;

Hess, SE ;

Kogej, T ;

Levin, MD ;

Marder, SR ;

McCord-Maughon, D ;

Perry, JW ;

Röckel, H ;

Rumi, M ;

Subramaniam, C ;

Webb, WW ;

Wu, XL ;

Xu, C .

SCIENCE, 1998, 281 (5383) :1653-1656

[2] Photosensitizers in clinical PDT [J].

Allison, Ron R. ;

Downie, Gordon H. ;

Cuenca, Rosa ;

Hu, Xin-Hua ;

Childs, Carter J. H. ;

Sibata, Claudio H. .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2004, 1 (01) :27-42

[3] Excitonically Coupled Oligomers and Dendrimers for Two-Photon Absorption [J].

Andraud, Chantal ;

Fortrie, Remy ;

Barsu, Cyril ;

Stephan, Olivier ;

Chermette, Henry ;

Baldeck, Patrice L. .

PHOTORESPONSIVE POLYMERS II, 2008, 214 :149-203

[4]

[Anonymous], 1985, SINGLET OXYGEN

[5]

Bonnett Alastair., 2000, ANTIRACISM

[6] PHOTOSENSITIZERS OF THE PORPHYRIN AND PHTHALOCYANINE SERIES FOR PHOTODYNAMIC THERAPY [J].

BONNETT, R .

CHEMICAL SOCIETY REVIEWS, 1995, 24 (01) :19-33

[7] Photosensitized singlet oxygen and its applications [J].

DeRosa, MC ;

Crutchley, RJ .

COORDINATION CHEMISTRY REVIEWS, 2002, 233 :351-371

[8] Current clinical and preclinical photosensitizers for use in photodynamic therapy [J].

Detty, MR ;

Gibson, SL ;

Wagner, SJ .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (16) :3897-3915

[9] Photodynamic therapy for cancer [J].

Dolmans, DEJGJ ;

Fukumura, D ;

Jain, RK .

NATURE REVIEWS CANCER, 2003, 3 (05) :380-387

[10] PHOTOSENSITIZED OXYGENATIONS AND ROLE OF SINGLET OXYGEN [J].

FOOTE, CS .

ACCOUNTS OF CHEMICAL RESEARCH, 1968, 1 (04) :104-&

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