The evolution of the MHC-G gene does not support a functional role for the complete protein

被引：8

作者：

Arnaiz-Villena, A ^{[1
]}

Martinez-Laso, J ^{[1
]}

Castro, MJ ^{[1
]}

Morales, P ^{[1
]}

Moscoso, J ^{[1
]}

Varela, P ^{[1
]}

Gomez-Casado, E ^{[1
]}

Allende, LM ^{[1
]}

机构：

[1] Univ Complutense Madrid, Hosp 12 Octubre, Dept Immunol & Mol Biol, Madrid 28041, Spain

来源：

IMMUNOLOGICAL REVIEWS | 2001年 / 183卷

关键词：

D O I：

10.1034/j.1600-065x.2001.1830105.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The study of the MHC-G gene evolution during nearly 40 million years does not support a role for the full molecule. The MHC-Glike proteins of New World monkeys are probably classical presenting molecules. Old World Cercopithecinae monkeys do not have a full MHC-G molecule and human individuals homozygous for the HLA-G null allele axe healthy and do not show birth pathologies.

引用

页码：65 / 75

页数：11

共 69 条

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