The evolution of the MHC-G gene does not support a functional role for the complete protein

被引：8
作者：
Arnaiz-Villena, A [1 ]
Martinez-Laso, J [1 ]
Castro, MJ [1 ]
Morales, P [1 ]
Moscoso, J [1 ]
Varela, P [1 ]
Gomez-Casado, E [1 ]
Allende, LM [1 ]
机构：
[1] Univ Complutense Madrid, Hosp 12 Octubre, Dept Immunol & Mol Biol, Madrid 28041, Spain
来源：
IMMUNOLOGICAL REVIEWS | 2001年 / 183卷
关键词：
D O I：
10.1034/j.1600-065x.2001.1830105.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The study of the MHC-G gene evolution during nearly 40 million years does not support a role for the full molecule. The MHC-Glike proteins of New World monkeys are probably classical presenting molecules. Old World Cercopithecinae monkeys do not have a full MHC-G molecule and human individuals homozygous for the HLA-G null allele axe healthy and do not show birth pathologies.
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收藏
页码：65 / 75
页数：11
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