Amyloidogenic processing of β-amyloid precursor protein in intracellular compartments

被引：154
|
作者：
Vetrivel, KS [1 ]
Thinakaran, G [1 ]
机构：
[1] Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Chicago, IL 60637 USA
来源：
NEUROLOGY | 2006年 / 66卷
关键词：
D O I：
10.1212/01.wnl.0000192107.17175.39
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations in the past two decades, since the identification of A beta as the principal component of brain senile plaques and the cloning of APP cDNA. Tremendous progress has been made in the recent past toward the characterization of beta-and gamma-secretases. Here, we review the salient features of Alzheimer disease amyloidogenesis, and discuss the current knowledge on APP trafficking and amyloidogenic processing of APP in intracellular membrane compartments and microdomains.
引用
收藏
页码：S69 / S73
页数：5
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