Amyloidogenic processing of β-amyloid precursor protein in intracellular compartments

被引：154

作者：

Vetrivel, KS ^{[1
]}

Thinakaran, G ^{[1
]}

机构：

[1] Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Chicago, IL 60637 USA

来源：

NEUROLOGY | 2006年 / 66卷

关键词：

D O I：

10.1212/01.wnl.0000192107.17175.39

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations in the past two decades, since the identification of A beta as the principal component of brain senile plaques and the cloning of APP cDNA. Tremendous progress has been made in the recent past toward the characterization of beta-and gamma-secretases. Here, we review the salient features of Alzheimer disease amyloidogenesis, and discuss the current knowledge on APP trafficking and amyloidogenic processing of APP in intracellular membrane compartments and microdomains.

引用

页码：S69 / S73

页数：5

共 39 条

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