Stereoselective synthesis of (+)-CP-99,994: A substance P non-peptide antagonist.

被引：40

作者：

Chandrasekhar, S ^{[1
]}

Mohanty, PK ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 27期

关键词：

stereoselective; nonchelation control; one-pot reactions; piperidine; (+)-CP-99,994;

D O I：

10.1016/S0040-4039(99)00983-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly stereoflexible total synthesis of(+)-CP-99,994 is achieved starting, from (S)-serine. key steps being a diastereoselective Grignard addition, a one-pot reductive protection of an azide, and one-pot oxidative Wittig olefination. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：5071 / 5072

页数：2

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