Individual-based network model for Rift Valley fever in Kabale District, Uganda

被引:6
作者
Sekamatte, Musa [1 ]
Riad, Mahbubul H. [2 ]
Tekleghiorghis, Tesfaalem [3 ]
Linthicum, Kenneth J. [4 ]
Britch, Seth C. [4 ]
Richt, Juergen A. [3 ]
Gonzalez, J. P. [3 ]
Scoglio, Caterina M. [2 ]
机构
[1] Minist Hlth, NOHP, ZDCO, Kampala, Uganda
[2] Kansas State Univ, Dept Elect & Comp Engn, Coll Engn, Manhattan, KS 66506 USA
[3] Kansas State Univ, Coll Vet Med, Dept Diagnost Med Pathobiol, Manhattan, KS 66506 USA
[4] USDA ARS, Ctr Med Agr & Vet Entomol, Gainesville, FL USA
来源
PLOS ONE | 2019年 / 14卷 / 03期
基金
美国农业部;
关键词
EPIDEMIC; OUTBREAK; VIRUS;
D O I
10.1371/journal.pone.0202721
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Rift Valley fever (RVF) is a zoonotic disease, that causes significant morbidity and mortality among ungulate livestock and humans in endemic regions. In East Africa, the causative agent of the disease is Rift Valley fever virus (RVFV) which is primarily transmitted by multiple mosquito species in Aedes and Mansonia genera during both epizootic and enzootic periods in a complex transmission cycle largely driven by environmental and climatic factors. However, recent RVFV activity in Uganda demonstrated the capability of the virus to spread into new regions through livestock movements, and underscored the need to develop effective mitigation strategies to reduce transmission and prevent spread among cattle populations. We simulated RVFV transmission among cows in 22 different locations of the Kabale District in Uganda using real world livestock data in a network-based model. This model considered livestock as a spatially explicit factor in different locations subjected to specific vector and environmental factors, and was configured to investigate and quantitatively evaluate the relative impacts of mosquito control, livestock movement, and diversity in cattle populations on the spread of the RVF epizootic. We concluded that cattle movement should be restricted for periods of high mosquito abundance to control epizootic spreading among locations during an RVF outbreak. Importantly, simulation results also showed that cattle populations with heterogeneous genetic diversity as crossbreeds were less susceptible to infection compared to homogenous cattle populations.
引用
收藏
页数:19
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