Molecular Characterization of Methicillin-Sensitive Staphylococcus aureus Isolates from Bacteremic Patients in a Norwegian University Hospital

被引：23
作者：
Blomfeldt, Anita [1 ]
Aamot, Hege Vangstein [1 ,2 ]
Eskesen, Arne N. [3 ]
Mueller, Fredrik [4 ]
Monecke, Stefan [5 ,6 ]
机构：
[1] Akershus Univ Hosp, Dept Microbiol & Infect Control, Lorenskog, Norway
[2] Akershus Univ Hosp, Dept Clin Mol Biol & Lab Sci EpiGen, Div Med, Oslo, Norway
[3] Akershus Univ Hosp, Dept Infect Dis, Lorenskog, Norway
[4] Univ Oslo, Rikshosp, Oslo Univ Hosp, Dept Microbiol, N-0027 Oslo, Norway
[5] Med Fac Carl Gustav Carus, Inst Med Microbiol & Hyg, Dresden, Germany
[6] Alere Technol GmbH, Jena, Germany
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2013年 / 51卷 / 01期
关键词：
POTENTIAL ASSOCIATIONS; NASAL CARRIAGE; RESISTANT; POPULATION; MORTALITY; GENOTYPE; GENES;
D O I：
10.1128/JCM.02571-12
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Staphylococcus aureus bacteremia is common in both nosocomial and community settings, and the pathogenicity of the microbe depends upon a large repertoire of virulence factors. S. aureus bacteremia isolates (n = 126) were characterized using DNA microarrays. Clonal complexes 5, 8, 15, 30, and 45 accounted for 74.6% of the isolates. We identified geographical differences in dominating clones and toxin gene profiles. One isolate was methicillin resistant. Potential associations between age and genotype were detected.
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收藏
页码：345 / 347
页数：3
相关论文
共 22 条
[1]   Molecular characterisation of methicillin-sensitive Staphylococcus aureus from deep surgical site infections in orthopaedic patients [J].
Aamot, H. V. ;
Blomfeldt, A. ;
Skramm, I. ;
Muller, F. ;
Monecke, S. .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2012, 31 (08) :1999-2004
[2]   Genotyping of 353 Staphylococcus aureus Bloodstream Isolates Collected between 2004 and 2009 at a Norwegian University Hospital and Potential Associations with Clinical Parameters [J].
Aamot, Hege Vangstein ;
Blomfeldt, Anita ;
Eskesen, Arne N. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (09) :3111-3114
[3]   Staphylococcus aureus:: A well-armed pathogen [J].
Archer, GL .
CLINICAL INFECTIOUS DISEASES, 1998, 26 (05) :1179-1181
[4]   Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia:: A meta-analysis [J].
Cosgrove, SE ;
Sakoulas, G ;
Perencevich, EN ;
Schwaber, MJ ;
Karchmer, AW ;
Carmeli, Y .
CLINICAL INFECTIOUS DISEASES, 2003, 36 (01) :53-59
[5]   Meticillin-resistant Staphylococcus aureus in Norway, a low-incidence country, 2006-2010 [J].
Elstrom, P. ;
Kacelnik, O. ;
Bruun, T. ;
Iversen, B. ;
Hauge, S. H. ;
Aavitsland, P. .
JOURNAL OF HOSPITAL INFECTION, 2012, 80 (01) :36-40
[6]   Evolution and pathogenesis of Staphylococcus aureus:: lessons learned from genotyping and comparative genomics [J].
Feng, Ye ;
Chen, Chih-Jung ;
Su, Lin-Hui ;
Hu, Songnian ;
Yu, Jun ;
Chiu, Cheng-Hsun .
FEMS MICROBIOLOGY REVIEWS, 2008, 32 (01) :23-37
[7]   Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection [J].
Fowler, Vance G., Jr. ;
Nelson, Charlotte L. ;
McIntyre, Lauren M. ;
Kreiswirth, Barry N. ;
Monk, Alastair ;
Archer, Gordon L. ;
Federspiel, Jerome ;
Naidich, Steven ;
Remortel, Brian ;
Rude, Thomas ;
Brown, Pamela ;
Reller, L. Barth ;
Corey, G. Ralph ;
Gill, Steven R. .
JOURNAL OF INFECTIOUS DISEASES, 2007, 196 (05) :738-747
[8]   Clinical identifiers of complicated Staphylococcus aureus bacteremia [J].
Fowler, VG ;
Olsen, MK ;
Corey, GR ;
Woods, CW ;
Cabell, CH ;
Reller, LB ;
Cheng, AC ;
Dudley, T ;
Oddone, EZ .
ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (17) :2066-2072
[9]  
Gagliotti C, 2011, EURO SURVEILL, V16
[10]   Clonal distribution of superantigen genes in clinical Staphylococcus aureus isolates [J].
Holtfreter, S. ;
Grumann, D. ;
Schmudde, M. ;
Nguyen, H. T. T. ;
Eichler, P. ;
Strommenger, B. ;
Kopron, K. ;
Kolata, J. ;
Giedrys-Kalemba, S. ;
Steinmetz, I. ;
Witte, W. ;
Broeker, B. M. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (08) :2669-2680
123