Association of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts

被引：7
|
作者：
Sanz-de-Galdeano, Anna [1 ,2 ,3 ]
Terskaya, Anastasia [4 ]
Upegui, Angie [1 ]
机构：
[1] Univ Alicante, FAE, Alicante, Spain
[2] Inst Lab Econ, Bonn, Germany
[3] CRES UPF, Barcelona, Spain
[4] Univ Navarra, Sch Econ & Business, Pamplona, Spain
来源：
PLOS ONE | 2020年 / 15卷 / 09期
关键词：
BODY-MASS INDEX; GENOME-WIDE; OBESITY; WEIGHT; BIRTH; ENVIRONMENT; ADOLESCENT; VARIANTS; AGE; SELECTION;
D O I：
10.1371/journal.pone.0239067
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We use data from the National Longitudinal Study of Adolescent to Adult Health and from the Health and Retirement Study to explore how the effect of individuals' genetic predisposition to higher BMI -measured by BMI polygenic scores- changes over the life-cycle for several cohorts. We find that the effect of BMI polygenic scores on BMI increases significantly as teenagers transition into adulthood (using the Add Health cohort, born 1974-83). However, this is not the case for individuals aged 55+ who were born in earlier HRS cohorts (1931-53), whose life-cycle pattern of genetic influence on BMI is remarkably stable as they move into old-age.
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页数：19
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