Complementary stereoselective conjugate addition reactions on indolo[2,3-α]-quinolizine templates

被引：19

作者：

Allin, SM ^{[1
]}

Khera, JS

Thomas, CI

Witherington, J

Doyle, K

Elsegood, MRJ

Edgar, M

机构：

[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] GlaxoSmithKline Res Ltd, Dept Med Chem, Neurol & GI Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England

[3] OSI Pharmaceut, Oxford OX4 6LT, England

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 12期

关键词：

D O I：

10.1016/j.tetlet.2006.01.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a new and highly stereoselective approach for the construction of a range of functionalized indolo[2,3-a]quinolizine targets from a readily available, nonracemic chiral template. The methods developed allow us to predetermine relative product stereochemistries by judicious choice of substrate sub-structure. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1961 / 1964

页数：4

共 18 条

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