Alternative strategies for the stereoselective synthesis of enantioenriched 6-arylated piperidin-2-ones

被引：11
|
作者：
Sallio, Romain [1 ,2 ]
Lebrun, Stephane [1 ,2 ]
Agbossou-Niedercorn, Francine [1 ,3 ,4 ]
Michon, Christophe [1 ,3 ,4 ]
Deniau, Eric [1 ,2 ]
机构：
[1] Univ Lille Nord France, F-59000 Lille, France
[2] Univ Lille 1, EA CMF 4478, Chim Organ Phys Lab, F-59655 Villeneuve Dascq, France
[3] UCCS, CNRS, UMR 8181, F-59655 Villeneuve Dascq, France
[4] ENSCL, CCM CCCF, F-59652 Villeneuve Dascq, France
来源：
TETRAHEDRON-ASYMMETRY | 2012年 / 23卷 / 13期
关键词：
HIGHLY ENANTIOSELECTIVE HYDROGENATION; ASYMMETRIC-SYNTHESIS; CATALYZED HYDROGENATION; SUZUKI-MIYAURA; PHOSPHATES; ALKALOIDS; CYCLOADDITION; COMPLEX; BOND; N; N-DIALKYLHYDRAZONES;
D O I：
10.1016/j.tetasy.2012.06.024
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two alternative synthetic approaches to a variety of enantioenriched 6-arylated piperidin-2-ones have been developed. The first one is based on the hydrogenation of suitably arylated chiral cyclic enehydrazides. The second approach relies on the asymmetric catalytic hydrogenation of the corresponding N-alkylated precursors. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：998 / 1004
页数：7
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