Evolution of dosage compensation under sexual selection differs between X and Z chromosomes

被引：42

作者：

Mullon, Charles ^{[1
,2
,3
]}

Wright, Alison E. ^{[1
,4
]}

Reuter, Max ^{[1
]}

Pomiankowski, Andrew ^{[1
,2
]}

Mank, Judith E. ^{[1
]}

机构：

[1] UCL, Dept Genet Evolut & Environm, London WC1E 6BT, England

[2] UCL, CoMPLEX, London WC1E 6BT, England

[3] Univ Lausanne, Dept Ecol & Evolut, Biophore, CH-1015 Lausanne, Switzerland

[4] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

基金：

英国工程与自然科学研究理事会; 欧洲研究理事会; 英国自然环境研究理事会; 瑞士国家科学基金会;

关键词：

EFFECTIVE POPULATION-SIZE; GENE-EXPRESSION LEVELS; DROSOPHILA; COMPLEX; ALIGNMENT; VARIANCE; PROTEINS; SEQUENCE; NUMBER; GENOME;

D O I：

10.1038/ncomms8720

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Complete sex chromosome dosage compensation has more often been observed in XY than ZW species. In this study, using a population genetic model and the chicken transcriptome, we assess whether sexual conflict can account for this difference. Sexual conflict over expression is inevitable when mutation effects are correlated across the sexes, as compensatory mutations in the heterogametic sex lead to hyperexpression in the homogametic sex. Coupled with stronger selection and greater reproductive variance in males, this results in slower and less complete evolution of Z compared with X dosage compensation. Using expression variance as a measure of selection strength, we find that, as predicted by the model, dosage compensation in the chicken is most pronounced in genes that are under strong selection biased towards females. Our study explains the pattern of weak dosage compensation in ZW systems, and suggests that sexual selection plays a major role in shaping sex chromosome dosage compensation.

引用

页数：10

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