Patterning, specification, and differentiation in the developing hypothalamus

被引：67

作者：

Bedont, Joseph L. ^{[1
]}

Newman, Elizabeth A. ^{[1
]}

Blackshaw, Seth ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, High Throughput Biol Ctr, Baltimore, MD USA

[6] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY | 2015年 / 4卷 / 05期

关键词：

HORMONE GENE-EXPRESSION; SONIC-HEDGEHOG EXPRESSION; VENTRAL MIDLINE CELLS; MICE LACKING; HOMEODOMAIN PROTEIN; STEROIDOGENIC FACTOR-1; VERTEBRATE FOREBRAIN; TERMINAL DIFFERENTIATION; DEVELOPMENTAL REGULATION; SUPRACHIASMATIC NUCLEUS;

D O I：

10.1002/wdev.187

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Owing to its complex structure and highly diverse cell populations, the study of hypothalamic development has historically lagged behind that of other brain regions. However, in recent years, a greatly expanded understanding of hypothalamic gene expression during development has opened up new avenues of investigation. In this review, we synthesize existing work to present a holistic picture of hypothalamic development from early induction and patterning through nuclear specification and differentiation, with a particular emphasis on determination of cell fate. We will also touch on special topics in the field including the prosomere model, adult neurogenesis, and integration of migratory cells originating outside the hypothalamic neuroepithelium, and how these topics relate to our broader theme. (C) 2015 Wiley Periodicals, Inc.

引用

页码：445 / 468

页数：24

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