Epigenetic Therapy Leaps Ahead with Specific Targeting of EZH2

被引：25

作者：

Melnick, Ari ^{[1
,2
]}

机构：

[1] Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA

[2] Weill Cornell Med Coll, Dept Pharmacol, New York, NY 10065 USA

来源：

CANCER CELL | 2012年 / 22卷 / 05期

关键词：

B-CELL LYMPHOMAS; METHYLATION; H3K27;

D O I：

10.1016/j.ccr.2012.10.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Polycomb epigenetic silencing protein EZH2 is affected by gain-of-function somatic mutations in B cell lymphomas. Two recent reports describe the development of highly selective EZH2 inhibitors and reveal mutant EZH2 as playing an essential role in maintaining lymphoma proliferation. EZH2 inhibitors are thus a promising new targeted therapy for lymphoma.

引用

页码：569 / 570

页数：2

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[21] Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2 [J].

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Rai, Aswathy N. ;

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[22] Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis [J].

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[23] An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1 [J].

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