Two-vial, LC-MS identification of ephedrine receptors from a solution-phase dynamic combinatorial library of over 9000 components

被引：54

作者：

Ludlow, R. Frederick ^{[1
]}

Otto, Sijbren ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 37期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ja803317k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reports on dynamic combinatorial chemistry have almost exclusively involved small libraries of 10-100 compounds. We now show how more than 9000 compounds can be screened in a single LC-MS analysis to reveal a series of new receptors that bind ephedrine in water. These results demonstrate the feasibility of screening DCLs that are substantially larger than the solution-phase libraries reported thus far.

引用

页码：12218 / +

页数：3

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