Interactions of Antimicrobial Peptides with Bacterial Membranes and Membrane Components

被引：59

作者：

Malmsten, Martin ^{[1
]}

机构：

[1] Uppsala Univ, Dept Pharm, SE-75123 Uppsala, Sweden

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 01期

基金：

瑞典研究理事会;

关键词：

AMP; Anti-inflammatory; Antimicrobial; Bacteria; Membrane; Peptide; HOST-DEFENSE PEPTIDES; C-TERMINAL PEPTIDES; LIPOPOLYSACCHARIDE INTERACTIONS; BIOPHYSICAL CHARACTERIZATION; CATHELICIDIN FAMILY; ACTION MECHANISM; HUMAN THROMBIN; ANTIBACTERIAL; LIPOPEPTIDES; PEGYLATION;

D O I：

10.2174/1568026615666150703121518

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antimicrobial peptides (AMPs) have attracted considerable recent interest as potential therapeutics, motivated by increasing resistance development against conventional antibiotics. This brief overview summarizes some key aspects related to the interaction of AMPs with bacterial and cell membranes, as well as with membrane components, which is at the core of the mode-of-action of these compounds. Throughout, studies on peptide interactions with model lipid membranes and membrane components are correlated to biological results on antimicrobial and anti-inflammatory effects of AMPs, and translated into therapeutic considerations.

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页码：16 / 24

页数：9

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