DNA methylation pathways and their crosstalk with histone methylation

被引：677

作者：

Du, Jiamu ^{[1
]}

Johnson, Lianna M. ^{[2
,3
]}

Jacobsen, Steven E. ^{[2
,3
]}

Patel, Dinshaw J. ^{[4
]}

机构：

[1] Chinese Acad Sci, Shanghai Ctr Plant Stress Biol, Shanghai Inst Biol Sci, Shanghai 201602, Peoples R China

[2] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA

[4] Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10065 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2015年 / 16卷 / 09期

关键词：

EMBRYONIC STEM-CELLS; LYSINE METHYLTRANSFERASE G9A; GENOME-WIDE; SRA DOMAIN; ENDOGENOUS RETROVIRUSES; EPIGENETIC INHERITANCE; STRUCTURAL INSIGHT; REPEATED SEQUENCES; SATELLITE REPEATS; CPG METHYLATION;

D O I：

10.1038/nrm4043

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal connections between these two epigenetic marks, and these domains mediate much of the crosstalk.

引用

页码：519 / 532

页数：14

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