Building Bridges: Leveraging Interdisciplinary Collaborations in the Development of Biomaterials to Meet Clinical Needs

被引:62
作者
Fong, Eliza L. S. [1 ]
Watson, Brendan M. [1 ]
Kasper, F. Kurtis [1 ]
Mikos, Antonios G. [1 ]
机构
[1] Rice Univ, Dept Bioengn, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
biomaterials; scaffolds; drug delivery; cartilage tissue engineering; bone tissue engineering; OLIGO(POLY(ETHYLENE GLYCOL) FUMARATE); MARROW STROMAL CELLS; MESENCHYMAL STEM-CELLS; BONE MORPHOGENETIC PROTEIN-2; CATIONIZED GELATIN MICROSPHERES; INJECTABLE HYDROGEL COMPOSITES; MINERALIZED MATRIX DEPOSITION; CROSS-LINKING CHARACTERISTICS; NONVIRAL GENE-DELIVERY; GROWTH-FACTOR DELIVERY;
D O I
10.1002/adma.201201762
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Our laboratory at Rice University has forged numerous collaborations with clinicians and basic scientists over the years to advance the development of novel biomaterials and the modification of existing materials to meet clinical needs. This review highlights collaborative advances in biomaterials research from our laboratory in the areas of scaffold development, drug delivery, and gene therapy, especially as related to applications in bone and cartilage tissue engineering.
引用
收藏
页码:4995 / 5013
页数:19
相关论文
共 171 条
[71]   Synthesis of poly(propylene fumarate) [J].
Kasper, F. Kurtis ;
Tanahashi, Kazuhiro ;
Fisher, John P. ;
Mikos, Antonios G. .
NATURE PROTOCOLS, 2009, 4 (04) :518-525
[72]   In vivo release of plasmid DNA from composites of oligo(poly(ethylene glycol)fumarate) and cationized gelatin microspheres [J].
Kasper, FK ;
Kushibiki, T ;
Kimura, Y ;
Mikos, AG ;
Tabata, Y .
JOURNAL OF CONTROLLED RELEASE, 2005, 107 (03) :547-561
[73]   In vitro release of plasmid DNA from oligo(poly(ethylene glycol) fumarate) hydrogels [J].
Kasper, FK ;
Seidlits, SK ;
Tang, A ;
Crowther, RS ;
Carney, DH ;
Barry, MA ;
Mikos, AG .
JOURNAL OF CONTROLLED RELEASE, 2005, 104 (03) :521-539
[74]  
Kessler Michael W, 2008, Organogenesis, V4, P28
[75]   Tissue engineering of bone: Material and matrix considerations [J].
Khan, Yusuf ;
Yaszemski, Michael J. ;
Mikos, Antonios G. ;
Laurencin, Cato T. .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2008, 90A :36-42
[76]   Early osteogenic signal expression of rat bone marrow stromal cells is influenced by both hydroxyapatite nanoparticle content and initial cell seeding density in biodegradable nanocomposite scaffolds [J].
Kim, Kyobum ;
Dean, David ;
Lu, Anqi ;
Mikos, Antonios G. ;
Fisher, John P. .
ACTA BIOMATERIALIA, 2011, 7 (03) :1249-1264
[77]   WATER-STRUCTURE AND CHANGES IN THERMAL-STABILITY OF THE SYSTEM POLY(ETHYLENE OXIDE)-WATER [J].
KJELLANDER, R ;
FLORIN, E .
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS I, 1981, 77 :2053-+
[78]   Thermoresponsive, in situ cross-linkable hydrogels based on N-isopropylacrylamide: Fabrication, characterization and mesenchymal stem cell encapsulation [J].
Klouda, Leda ;
Perkins, Kevin R. ;
Watson, Brendan M. ;
Hacker, Michael C. ;
Bryant, Stephanie J. ;
Raphael, Robert M. ;
Kasper, F. Kurtis ;
Mikos, Antonios G. .
ACTA BIOMATERIALIA, 2011, 7 (04) :1460-1467
[79]   Cytocompatibility evaluation of amphiphilic, thermally responsive and chemically crosslinkable macromers for in situ forming hydrogels [J].
Klouda, Leda ;
Hacker, Michael C. ;
Kretlow, James D. ;
Mikos, Antonios G. .
BIOMATERIALS, 2009, 30 (27) :4558-4566
[80]   Evaluation of Soft Tissue Coverage over Porous Polymethylmethacrylate Space Maintainers Within Nonhealing Alveolar Bone Defects [J].
Kretlow, James D. ;
Shi, Meng ;
Young, Simon ;
Spicer, Patrick P. ;
Demian, Nagi ;
Jansen, John A. ;
Wong, Mark E. ;
Kasper, F. Kurtis ;
Mikos, Antonios G. .
TISSUE ENGINEERING PART C-METHODS, 2010, 16 (06) :1427-1438