Symptom combinations assessed in traditional Chinese medicine and its predictive role in ACR20 efficacy response in rheumatoid arthritis

被引：21

作者：

He, Yiting ^{[3
]}

Lu, Aiping ^{[1
,2
]}

Lu, Cheng ^{[1
,2
]}

Zha, Yinglin ^{[4
]}

Yan, Xiaoping ^{[5
]}

Song, Yuejin ^{[6
]}

Zeng, Shengping ^{[7
]}

Liu, Wei ^{[8
]}

Zhu, Wanhua ^{[9
]}

Su, Li ^{[10
]}

Feng, Xinghua ^{[11
]}

Qian, Xian ^{[12
]}

Tsang, Ian ^{[13
]}

机构：

[1] Chinese Acad Tradit Chinese Med, Inst Basic Res Clin Med, Beijing 100700, Peoples R China

[2] Shanghai TCM Univ, E Inst Shanghai Municipal Educ Commiss, Shanghai, Peoples R China

[3] Guangdong Tradit Chinese Med Hosp, Guangzhou, Guangdong, Peoples R China

[4] Jiangxi TCM Univ, Nanchang, Peoples R China

[5] Sino Japan Friendship Hosp, Beijing, Peoples R China

[6] Hubei Tradit Chinese Med Acad, Wuhan, Peoples R China

[7] Chengdu TCM Univ, Affiliated Hosp, Chengdu, Peoples R China

[8] Tianjin Tradit Chinese Med Coll, Affiliated Hosp, Tianjin, Peoples R China

[9] Nantong Liangchun TCM Clin Res Inst, Nantong, Peoples R China

[10] Shanghai Tradit Chinese Med Univ, Longhua Affiliated Hosp, Shanghai, Peoples R China

[11] Chinese Acad Tradit Chinese Med, Guanganmen Hosp, Beijing 100700, Peoples R China

[12] Jiangsu Tradit Chinese Med Hosp, Nanjing, Peoples R China

[13] Univ British Columbia, Arthrit Res Ctr, Vancouver, BC V5Z 1M9, Canada

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2008年 / 36卷 / 04期

关键词：

symptoms; efficacy; rheumatoid arthritis;

D O I：

10.1142/S0192415X08006144

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The predictive roles of symptom combination traditionally evaluated in traditional Chinese medicine (TCM) in the treatment of rheumatoid arthritis (RA) were explored. Three hundred and ninety six patients were randomly divided into 197 subjects receiving Western medicine therapy (WM) and 199 subjects receiving TCM therapy (TCM). A complete physical examination and 18 clinical manifestations typically assessed in TCM were recorded before the randomization. The ACR responses were used for efficacy evaluation. ACR20 and 50 responses with WM treatment were higher than in the TCM group. The 18 symptoms in RA could be clustered into 4 symptom combinations with factor analysis, which represent joint symptoms, cold pattern, deficiency pattern and hot pattern in TCM respectively. TCM would be more effective in patients with weak-symptom combination 3 (deficiency pattern in TCM), and WM would be more effective in patients with symptom combination 2 (cold pattern in TCM). Symptom combinations judged with TCM may have influence on the efficacy of therapy in the treatment of RA.

引用

页码：675 / 683

页数：9

共 14 条

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