Selenium stimulates pancreatic beta-cell gene expression and enhances islet function

被引：51

作者：

Campbell, Susan C. ^{[2
]}

Aldibbiat, Ali ^{[2
]}

Marriott, Claire E. ^{[1
]}

Landy, Caroline ^{[1
]}

Ali, Tomader ^{[1
]}

Ferris, William F. ^{[3
]}

Butler, Clive S. ^{[4
]}

Shaw, James A. ^{[2
]}

Macfarlane, Wendy M. ^{[1
]}

机构：

[1] Univ Brighton, Sch Pharm & Biomol Sci, Brighton BN2 4GJ, E Sussex, England

[2] Univ Newcastle, Inst Cell & Mol Biosci, Newcastle Upon Tyne, Tyne & Wear, England

[3] Univ Stellenbosch, Endocrinol & Metab Unit, ZA-7600 Stellenbosch, South Africa

[4] Univ Exeter, Sch Biosci, Exeter EX4 4QJ, Devon, England

来源：

FEBS LETTERS | 2008年 / 582卷 / 15期

基金：

英国生物技术与生命科学研究理事会;

关键词：

beta-cell; islets of Langerhans; transcription; selenium; Ipf1;

D O I：

10.1016/j.febslet.2008.05.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the -2715 to -1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2333 / 2337

页数：5

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