Cerebrovascular Assessment for the Risk Prediction of Alzheimer's Disease

被引：30

作者：

Silvestrini, Mauro ^{[1
]}

Viticchi, Giovanna ^{[1
]}

Altamura, Claudia ^{[2
]}

Luzzi, Simona ^{[1
]}

Balucani, Clotilde ^{[3
]}

Vernieri, Fabrizio ^{[2
]}

机构：

[1] Univ Politecn Marche, Neurol Clin, I-60020 Ancona, Italy

[2] Campus Biomed Univ, Neurol Clin, Rome, Italy

[3] Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2012年 / 32卷 / 03期

关键词：

Alzheimer's disease; vascular markers; vascular risk factors; WHITE-MATTER LESIONS; MILD COGNITIVE IMPAIRMENT; INTIMA-MEDIA THICKNESS; CEREBRAL VASOMOTOR REACTIVITY; GLYCATION END-PRODUCTS; MIDLIFE BLOOD-PRESSURE; APOLIPOPROTEIN-E; CAROTID ATHEROSCLEROSIS; AMYLOID-BETA; ATRIAL-FIBRILLATION;

D O I：

10.3233/JAD-2012-121240

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Increasing evidence is emerging that vascular disease and its risk factors play a role in the development of Alzheimer's disease (AD) and affect the probability of an adverse outcome. The aims of this review are to explore the relationship between vascular risk factors and AD and to discuss the potential use of vascular markers in the clinical approach to cognitive impairment. Moreover, we present evidence about the potential use of ultrasonographic and neuroradiologic markers of cognitive impairment in order to establish possible treatment strategies in subjects with a clinical profile at risk of developing AD.

引用

页码：689 / 698

页数：10

共 93 条

[1] White Matter Damage in Alzheimer Disease and Its Relationship to Gray Matter Atrophy [J].

Agosta, Federica ;

Pievani, Michela ;

Sala, Stefania ;

Geroldi, Cristina ;

Galluzzi, Samantha ;

Frisoni, Giovanni B. ;

Filippi, Massimo .

RADIOLOGY, 2011, 258 (03) :853-863

[2]

Albert Marilyn, 2008, Handb Clin Neurol, V88, P511, DOI 10.1016/S0072-9752(07)88027-4

[3] What is the relationship among atherosclerosis markers, apolipoprotein E polymorphism and dementia? [J].

Altamura, C. ;

Squitti, R. ;

Pasqualetti, P. ;

Tibuzzi, F. ;

Silvestrini, M. ;

Ventriglia, M. C. ;

Cassetta, E. ;

Rossini, P. M. ;

Vernieri, F. .

EUROPEAN JOURNAL OF NEUROLOGY, 2007, 14 (06) :679-682

[4] Cholesterol as a risk factor for dementia and cognitive decline: A systematic review of prospective studies with meta-analysis [J].

Anstey, Kaarin J. ;

Lipnicki, Darren M. ;

Low, Lee-Fay .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2008, 16 (05) :343-354

[5] Cerebral vasomotor reactivity and cerebral white matter lesions in the elderly [J].

Bakker, SLM ;

de Leeuw, FE ;

de Groot, JC ;

Hofman, A ;

Koudstaal, PJ ;

Breteler, MMB .

NEUROLOGY, 1999, 52 (03) :578-583

[6] Transport of insulin across the blood-brain barrier: Saturability at euglycemic doses of insulin [J].

Banks, WA ;

Jaspan, JB ;

Huang, WT ;

Kastin, AJ .

PEPTIDES, 1997, 18 (09) :1423-1429

[7] Risk of Incident Dementia in Drug-Untreated Arterial Hypertension: A Population-Based Study [J].

Bermejo-Pareja, Felix ;

Benito-Leon, Julian ;

Louis, Elan D. ;

Trincado, Rocio ;

Carro, Eva ;

Villarejo, Alberto ;

Gomez de la Camara, Agustin .

JOURNAL OF ALZHEIMERS DISEASE, 2010, 22 (03) :949-958

[8] Type 2 Diabetes and Late-Onset Alzheimer's Disease [J].

Cheng, D. ;

Noble, J. ;

Tang, M. X. ;

Schupf, N. ;

Mayeux, R. ;

Luchsinger, J. A. .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2011, 31 (06) :424-430

[9] Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies [J].

Cheng, G. ;

Huang, C. ;

Deng, H. ;

Wang, H. .

INTERNAL MEDICINE JOURNAL, 2012, 42 (05) :484-491

[10] Impaired Cerebrovascular Reactivity With Steal Phenomenon Is Associated With Increased Diffusion in White Matter of Patients With Moyamoya Disease [J].

Conklin, John ;

Fierstra, Jorn ;

Crawley, Adrian P. ;

Han, Jay S. ;

Poublanc, Julien ;

Mandell, Daniel M. ;

Silver, Frank L. ;

Tymianski, Michael ;

Fisher, Joseph A. ;

Mikulis, David J. .

STROKE, 2010, 41 (08) :1610-1616

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