Facile one-pot synthesis of pyrido[2,3-d]pyrimidine derivatives over ZrO2 nanoparticles catalyst

被引：35

作者：

Abdolmohammadi, Shahrzad ^{[1
]}

Afsharpour, Maryam ^{[2
]}

机构：

[1] Islamic Azad Univ, E Tehran Branch, Dept Chem, Tehran, Iran

[2] Univ Tehran, Nano Sci & Technol Res Ctr, Tehran, Iran

来源：

CHINESE CHEMICAL LETTERS | 2012年 / 23卷 / 03期

关键词：

Pyrido[2,3-d]pyrimidines; Solvent-free; Tandem Knoevenagel-Michael addition; ZrO2; nanoparticles; AQUEOUS-MEDIA; PYRIDO<2,3-D>PYRIMIDINE DERIVATIVES; BIOLOGICAL-ACTIVITY; 3-COMPONENT; HYDROGENATION; ALUMINA; ACIDS;

D O I：

10.1016/j.cclet.2012.01.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of hexahydropyrido[2,3-d]pyrimidinetrione derivatives is achieved via tandem Knoevenagel-Michael addition of aromatic aldehydes, methylcyanoacetate and 4(6)-aminouracil in solvent-free conditions in the presence of 10 mol% of ZrO2 nanoparticles (ZrO2 NPs) as a heterogenous catalyst. The procedure is formed in high yields, short reaction time and an environmentally friendly specificity. (C) 2012 Shahrzad Abdolmohammadi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：257 / 260

页数：4

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