Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring

被引：7

作者：

Lecoutre, S. ^{[1
]}

Marousez, L. ^{[1
]}

Drougard, A. ^{[2
]}

Knauf, C. ^{[2
]}

Guinez, C. ^{[1
]}

Eberle, D. ^{[1
]}

Laborie, C. ^{[1
]}

Vieau, D. ^{[1
]}

Lesage, J. ^{[1
]}

Breton, C. ^{[1
]}

机构：

[1] Univ Lille, EA4489, Equipe Malnutr Maternelle & Programmat Malad Meta, F-59000 Lille, France

[2] INSERM, U1220, IRSD,Team 3, European Associated Lab NeuroMicrobiota INSERM UC, Toulouse, France

来源：

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE | 2017年 / 8卷 / 01期

关键词：

adipogenesis; apelin; APJ; fetal programming; HF diet; APJ RECEPTOR; MICE; OBESITY; EXPRESSION; INSULIN; LIGAND; ADIPOGENESIS; METHYLATION; LIPOLYSIS; TARGET;

D O I：

10.1017/S2040174416000702

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Based on the Developmental Origin of Health and Disease concept, maternal undernutrition has been shown to sensitize adult offspring to metabolic pathologies such as obesity. Using a model of maternal 70% food restriction in pregnant female rats throughout gestation (called FR30), we previously reported that obesity-prone adult male rat offspring displayed hyperleptinemia with modifications in leptin and leptin receptor messenger RNA (mRNA) levels in white adipose tissue (WAT). Apelin is a member of the adipokine family that regulates various aspects of energy metabolism and WAT functionality. We investigated whether apelin and its receptor APJ could be a target of maternal undernutrition. Adult male rat offspring from FR30 dams showed increased plasma apelin levels and apelin gene expression in WAT. Post-weaning high-fat diet led to marked increase in APJ mRNA and protein levels in offspring's WAT. We demonstrate that maternal undernutrition and post-weaning diet have long-term consequences on the apelinergic system of adult male rat offspring.

引用

页码：3 / 7

页数：5

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