Anemia and heart failure

被引：50

作者：

Ghali, Jalal K. ^{[1
]}

机构：

[1] Harper Univ Hosp, Detroit, MI USA

来源：

CURRENT OPINION IN CARDIOLOGY | 2009年 / 24卷 / 02期

关键词：

anemia; erythropoietin; heart failure; iron; CHRONIC KIDNEY-DISEASE; BLUNTED ERYTHROPOIETIN PRODUCTION; IRON-ABSORPTION TEST; INTRAVENOUS IRON; DARBEPOETIN-ALPHA; DOUBLE-BLIND; EXERCISE TOLERANCE; HEMOGLOBIN LEVEL; NEW-ONSET; MORTALITY;

D O I：

10.1097/HCO.0b013e328324ecec

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review The earlier enthusiasm for raising hemoglobin in heart failure has been followed by skepticism and concern of potential harm from using erythropoiesis-stimulating agents (ESAs). Recent findings Several recent studies have confirmed the high prevalence and prognostic role of anemia and have shown encouraging signals of the safety of using ESAs in heart failure and potential benefit that may be related to nonhematopoietic effects of ESAs. In addition, recent studies have also suggested a potential beneficial role of iron replacement in heart failure. Summary Despite the encouraging findings of these preliminary studies, the future role of ESAs and iron replacement will be determined by ongoing randomized placebo-controlled studies.

引用

收藏

页码：172 / 178

页数：7

相关论文

共 78 条

[21] Safety in iron management [J].

Fishbane, S .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2003, 41 (06) :S18-S26

[22] Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart [J].

Gao, Erhe ;

Boucher, Matthieu ;

Chuprun, J. Kurt ;

Zhou, Rui-Hai ;

Eckhart, Andrea D. ;

Koch, Walter J. .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (01) :H60-H68

[23] Circulating erythropoietin levels and prognosis in patients with congestive heart failure - Comparison with neurohormonal and inflammatory markers [J].

George, J ;

Patal, S ;

Wexler, D ;

Abashidze, A ;

Shmilovich, H ;

Barak, T ;

Sheps, D ;

Keren, G .

ARCHIVES OF INTERNAL MEDICINE, 2005, 165 (11) :1304-1309

[24] Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemia [J].

Ghali, Jalal K. ;

Anand, Inder S. ;

Abraham, William T. ;

Fonarow, Gregg C. ;

Greenberg, Barry ;

Krum, Henry ;

Massie, Barry M. ;

Wasserman, Scott M. ;

Trotman, Marie-Louise ;

Sun, Yan ;

Knusel, Beat ;

Armstrong, Paul .

CIRCULATION, 2008, 117 (04) :526-535

[25] Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure - The anemia in chronic heart failure: Outcomes and Resource Utilization (ANCHOR) Study [J].

Go, Alan S. ;

Yang, Jingrong ;

Ackerson, Lynn M. ;

Lepper, Krista ;

Robbins, Sean ;

Massie, Barry M. ;

Shlipak, Michael G. .

CIRCULATION, 2006, 113 (23) :2713-2723

[26] Anemia and mortality in heart failure patients - A systematic review and meta-analysis [J].

Groenveld, Hessel F. ;

Januzzi, James L. ;

Damman, Kevin ;

van Wijngaarden, Jan ;

Hillege, Hans L. ;

van Veldhuisen, Dirk J. ;

van der Meer, Peter .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (10) :818-827

[27] Iron and anemia in human biology: a review of mechanisms [J].

Handelman, Garry J. ;

Levin, Nathan W. .

HEART FAILURE REVIEWS, 2008, 13 (04) :393-404

[28] Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction [J].

Ishani, A ;

Weinhandl, E ;

Zhao, ZH ;

Gilbertson, DT ;

Collins, AJ ;

Yusuf, S ;

Herzog, CA .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 45 (03) :391-399

[29] Proinflammatory cytokines lowering erythropoietin production [J].

Jelkmann, W .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1998, 18 (08) :555-559

[30] Erythropoietin after a century of research: younger than ever [J].

Jelkmann, Wolfgang .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2007, 78 (03) :183-205

← 1 2 3 4 5 6 7 8 →