Cardiovascular Risk in Type 1 Diabetes Mellitus

被引：107

作者：

Schofield, Jonathan ^{[1
,2
]}

Ho, Jan ^{[2
,3
]}

Soran, Handrean ^{[2
,3
]}

机构：

[1] Manchester Univ Hosp NHS Fdn Trust, Manchester Royal Infirm, Manchester Acad Hlth Sci Ctr, Manchester Diabet Ctr, Manchester M13 9WL, Lancs, England

[2] Univ Manchester, Fac Biol Med & Hlth, Cardiovasc Res Grp, Manchester M13 9WU, Lancs, England

[3] Manchester Univ Hosp NHS Fdn Trust, Univ Dept Med, Manchester Acad Hlth Sci Ctr, Cardiovasc Trials Unit, Manchester M13 9WL, Lancs, England

来源：

DIABETES THERAPY | 2019年 / 10卷 / 03期

关键词：

Cardiovascular disease; Cardiovascular risk; Type 1 diabetes mellitus; DENSITY-LIPOPROTEIN CHOLESTEROL; ALL-CAUSE MORTALITY; C-REACTIVE PROTEIN; CORONARY-ARTERY CALCIFICATION; 14; RANDOMIZED-TRIALS; COMPLICATIONS TRIAL/EPIDEMIOLOGY; APOLIPOPROTEIN-B; LDL-CHOLESTEROL; HEART-DISEASE; ENDOTHELIAL DYSFUNCTION;

D O I：

10.1007/s13300-019-0612-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 1 diabetes mellitus (T1DM) is associated with premature cardiovascular disease (CVD), but the underlying mechanisms remain poorly understood. The American Diabetes Association and the European Association for the Study of Diabetes recently updated their position statement on the management of type 2 diabetes mellitus (T2DM) to include additional focus on cardiovascular risk; improved management of risk factors in T1DM is also needed. There are important differences in the pathophysiology of CVD in T1DM and T2DM. Hyperglycaemia appears to have a more profound effect on cardiovascular risk in T1DM than T2DM, and other risk factors appear to cause a synergistic rather than additive effect, so achievement of treatment targets for all recognized risk factors is crucial to reducing cardiovascular risk. Here we discuss the evidence for addressing established cardiovascular risk factors, candidate biomarkers and surrogate measurements, and possible interventions.

引用

页码：773 / 789

页数：17

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