Transcriptional control of RfaH on polysialic and colanic acid synthesis by Escherichia coli K92

被引：11

作者：

Navasa, Nicolas ^{[1
]}

Rodriguez-Aparicio, Leandro B. ^{[1
]}

Ferrero, Miguel Angel ^{[1
]}

Monteagudo-Mera, Andrea ^{[1
]}

Martinez-Blanco, Honorina ^{[1
]}

机构：

[1] Univ Leon, Dept Biol Mol, Area Bioquim & Biol Mol, E-24071 Leon, Spain

来源：

FEBS LETTERS | 2014年 / 588卷 / 06期

关键词：

Transcriptional antiterminator; Thermoregulation; Capsular polysaccharides; Gene expression; CAPSULE GENE-CLUSTER; ELONGATION-FACTOR RFAH; SIALIC-ACID; REGION; POLYSACCHARIDE; BIOSYNTHESIS; ORGANIZATION; SYSTEM; TEMPERATURE; EXPRESSION;

D O I：

10.1016/j.febslet.2014.01.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcriptional antiterminator RfaH promotes transcription of long operons encoding surface cell components important for the virulence of Escherichia coli pathogens. In this paper, we show that RfaH enhanced kps expression for the synthesis of group 2 polysialic acid capsule in E. coli K92. In addition, we demonstrate for the first time that RfaH promotes cps expression for the synthesis of colanic acid, a cell wall component with apparently no role on pathogenicity. Finally, we show a novel RfaH requirement for growth at low temperatures. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：922 / 928

页数：7

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