Statistical analysis of longitudinal neuroimage data with Linear Mixed Effects models

被引：288
作者：
Bernal-Rusiel, Jorge L. [1 ]
Greve, Douglas N. [1 ]
Reuter, Martin [1 ,2 ]
Fischl, Bruce [1 ,3 ]
Sabuncu, Mert R. [1 ,3 ]
机构：
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
[2] MIT, Dept Mech Engn, Cambridge, MA 02139 USA
[3] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA
来源：
NEUROIMAGE | 2013年 / 66卷
基金：
美国国家卫生研究院;
关键词：
Longitudinal studies; Linear Mixed Effects models; Statistical analysis; MILD COGNITIVE IMPAIRMENT; BRAIN VOLUME CHANGES; SURFACE-BASED ANALYSIS; GRAY-MATTER VOLUME; ALZHEIMERS-DISEASE; HIPPOCAMPAL ATROPHY; CORTICAL THICKNESS; 1ST-EPISODE SCHIZOPHRENIA; MAXIMUM-LIKELIHOOD; COORDINATE SYSTEM;
D O I：
10.1016/j.neuroimage.2012.10.065
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Longitudinal neuroimaging (LNI) studies are rapidly becoming more prevalent and growing in size. Today, no standardized computational tools exist for the analysis of LNI data and widely used methods are sub-optimal for the types of data encountered in real-life studies. Linear Mixed Effects (LME) modeling, a mature approach well known in the statistics community, offers a powerful and versatile framework for analyzing real-life LNI data. This article presents the theory behind LME models, contrasts it with other popular approaches in the context of LNI, and is accompanied with an array of computational tools that will be made freely available through FreeSurfer - a popular Magnetic Resonance Image (MRI) analysis software package. Our core contribution is to provide a quantitative empirical evaluation of the performance of LME and competing alternatives popularly used in prior longitudinal structural MRI studies, namely repeated measures ANOVA and the analysis of annualized longitudinal change measures (e.g. atrophy rate). In our experiments, we analyzed MRI-derived longitudinal hippocampal volume and entorhinal cortex thickness measurements from a public dataset consisting of Alzheimer's patients, subjects with mild cognitive impairment and healthy controls. Our results suggest that the LME approach offers superior statistical power in detecting longitudinal group differences. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：249 / 260
页数：12
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