Rh-catalyzed sequential oxidative C-H activation/annulation with geminal-substituted vinyl acetates to access isoquinolines

被引：96
|
作者：
Chu, Haoke [1 ]
Sun, Song [1 ]
Yu, Jin-Tao [1 ]
Cheng, Jiang [1 ]
机构：
[1] Changzhou Univ, Jiangsu Prov Key Lab Fine Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Sch Petrochem Engn, Changzhou 213164, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 68期
基金：
中国国家自然科学基金;
关键词：
BETA-PHENYLETHYLAMINES; INTERNAL ALKYNES; BOND ACTIVATION; PAPAVERINE; FUNCTIONALIZATION; DERIVATIVES; CYCLIZATION; ALKALOIDS; KETIMINES; ESTERS;
D O I：
10.1039/c5cc04708k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The concise synthesis of 3-substituted or non-C3-substituted isoquinolines through Rh-catalyzed sequential oxidative C-H activation/annulation with geminal-substituted vinyl acetates was developed with good functional group tolerance. The protocol was successfully applied to the total synthesis of the natural product papaverine.
引用
收藏
页码：13327 / 13329
页数：3
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