Controlling HIV pathogenesis: The role of the noncytotoxic anti-HIV response of CD8(+) T cells

被引：405

作者：

Levy, JA ^{[1
]}

Mackewicz, CE ^{[1
]}

Barker, E ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 05期

关键词：

D O I：

10.1016/0167-5699(96)10011-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Noncytotoxic CD8(+) T cells may play a critical role in preventing progression to disease following human immunodeficiency virus (HIV) infection. This antiviral response, mediated by a novel CD8(+) T-ceII antiviral factor (CAF), occurs soon after infection and is maintained in asymptomatic individuals. Here, Jay Levy and colleagues propose that this antiviral activity represents a natural cellular immune reaction that controls HIV production and protects the host from potential harmful effects of cytotoxic T lymphocytes.

引用

页码：217 / 224

页数：8

共 81 条

[1]

AUTRAN B, 1988, AIDS, V2, P179

[2] THE ROLE OF CD8-POSITIVE LYMPHOCYTES IN THE CONTROL OF HIV-1 INFECTION OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS [J].

BAGASRA, O ;

POMERANTZ, RJ .

IMMUNOLOGY LETTERS, 1993, 35 (02) :83-92

[3]

BALER M, 1995, NATURE, V378, P563

[4] EFFECTS OF T(H)1 AND T(H)2 CYTOKINES ON CD8(+) CELL RESPONSE AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS - IMPLICATIONS FOR LONG-TERM SURVIVAL [J].

BARKER, E ;

MACKEWICZ, CE ;

LEVY, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) :11135-11139

[5] UNLOCKING THE SECRETS OF CTL AND NK CELLS [J].

BERKE, G .

IMMUNOLOGY TODAY, 1995, 16 (07) :343-346

[6] WHY CANT CYTOTOXIC T-CELLS HANDLE HIV [J].

BEVAN, MJ ;

BRACIALE, TJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (13) :5765-5767

[7] VIRUS-SPECIFIC CD8+ CYTOTOXIC T-LYMPHOCYTE ACTIVITY ASSOCIATED WITH CONTROL OF VIREMIA IN PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION [J].

BORROW, P ;

LEWICKI, H ;

HAHN, BH ;

SHAW, GM ;

OLDSTONE, MBA .

JOURNAL OF VIROLOGY, 1994, 68 (09) :6103-6110

[8]

BRINCHMANN JE, 1990, J IMMUNOL, V144, P2961

[9] FREQUENCY OF PROVIRUS-BEARING CD4(+) CELLS IN HIV TYPE-1 INFECTION CORRELATES WITH EXTENT OF IN-VITRO APOPTOSIS OF CD8(+) BUT NOT OF CD4(+) CELLS [J].

CARBONARI, M ;

CIBATI, M ;

PESCE, AM ;

SBARIGIA, D ;

GROSSI, P ;

DOFFIZI, G ;

LUZI, G ;

FIORILLI, M .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 (07) :789-794

[10] QUANTITATIVE-ANALYSIS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-SPECIFIC CYTOTOXIC LYMPHOCYTE-T (CTL) RESPONSE AT DIFFERENT STAGES OF HIV-1 INFECTION - DIFFERENTIAL CTL RESPONSES TO HIV-1 AND EPSTEIN-BARR-VIRUS IN LATE DISEASE [J].

CARMICHAEL, A ;

JIN, X ;

SISSONS, P ;

BORYSIEWICZ, L .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) :249-256

← 1 2 3 4 5 6 7 8 9 →