Helicobacter pylori infection might have a potential role in hepatocyte ballooning in nonalcoholic fatty liver disease

被引：70

作者：

Sumida, Yoshio ^{[1
]}

Kanemasa, Kazuyuki ^{[2
]}

Imai, Shunsuke ^{[3
]}

Mori, Kojiro ^{[2
]}

Tanaka, Saiyu ^{[2
]}

Shimokobe, Hideto ^{[2
]}

Kitamura, Yoko ^{[2
]}

Fukumoto, Kohei ^{[2
]}

Kakutani, Akira ^{[2
]}

Ohno, Tomoyuki ^{[2
]}

Taketani, Hiroyoshi ^{[1
]}

Seko, Yuya ^{[1
]}

Ishiba, Hiroshi ^{[1
]}

Hara, Tasuku ^{[1
]}

Okajima, Akira ^{[1
]}

Yamaguchi, Kanji ^{[1
]}

Moriguchi, Michihisa ^{[1
]}

Mitsuyoshi, Hironori ^{[1
]}

Yasui, Kohichiroh ^{[1
]}

Minami, Masahito ^{[1
]}

Itoh, Yoshito ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Gastroenterol & Hepatol, Kamigyo Ku, Kyoto 6028566, Japan

[2] Nara City Hosp, Ctr Digest & Liver Dis, Nara, Japan

[3] Nara City Hosp, Dept Pathol, Nara, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2015年 / 50卷 / 09期

基金：

日本学术振兴会;

关键词：

Hepatocyte ballooning; Helicobacter pylori; Nonalcoholic steatohepatitis; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; JAPANESE POPULATION; METABOLIC SYNDROME; CHRONIC HEPATITIS; SCORING SYSTEM; STEATOHEPATITIS; ASSOCIATION; IRON; STOMACH;

D O I：

10.1007/s00535-015-1039-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Clinical data regarding Helicobacter pylori (H. pylori) infection in nonalcoholic fatty liver disease (NAFLD) are limited. The aim was to evaluate H. pylori infection in patients with NAFLD and its association with disease severity. One hundred and thirty patients with biopsy-proven NAFLD [43 with nonalcoholic fatty liver (NAFL) and 87 with nonalcoholic steatohepatitis (NASH)] were recruited for blood samples for anti-H. pylori immunoglobulin G (IgG) and standard biochemical tests were obtained after overnight fasting. Glucose tolerance was evaluated by 75-g oral glucose tolerance test. Liver biopsies were scored for NAFLD activity score (NAS), fibrosis and iron deposits. H. pylori IgG seropositivity was found in 40 % of patients overall. The prevalence of NASH was significantly higher in the patients with H. pylori IgG seropositivity (81 %) than in those without (58 %, p = 0.008). Glucose intolerance was similar between the two groups. The total NAS and the grade of hepatocyte ballooning were higher in the patients with H. pylori IgG seropositivity than in those without, while the hepatic iron grade was lower in the patients with H. pylori IgG seropositivity than in those without. H. pylori infection (p = 0.030), female gender (p = 0.029), and NAFIC score a parts per thousand yen 2 points (p < 0.001) could independently predict NASH in logistic regression analysis, independent of age, obesity and glucose tolerance. The association of H. pylori seropositivity with hepatocyte ballooning suggests that H. pylori infection may represent another contributing factor in the progression from NAFL to NASH. Eradicating H. pylori infection may have therapeutic prospects in NASH treatment.

引用

页码：996 / 1004

页数：9

共 53 条

[11] Association between Helicobacter pylori and liver-to-spleen ratio: a randomized-controlled single-blind study [J].