Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical cancer in Japanese

被引：47

作者：

Niwa, Y

Hamajima, N

Atsuta, Y

Yamamoto, K

Tamakoshi, A

Saito, T

Hirose, K

Nakanishi, T

Nawa, A

Kuzuya, K

Tajima, K

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Prevent Med Biostat & Med Decis Making, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Aichi Canc Ctr, Res Inst, Dept Epidemiol & Prevent, Chikusa Ku, Nagoya, Aichi 4648681, Japan

[3] Aichi Canc Ctr Hosp, Dept Gynecol, Chikusa Ku, Nagoya, Aichi 4648681, Japan

来源：

CANCER LETTERS | 2004年 / 205卷 / 01期

关键词：

p73 two linked polymorphism; p53 Arg72Pro polymorphism; cervical cancer; polymerase chain reaction with confronting two-pair primers;

D O I：

10.1016/j.canlet.2003.11.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To examine the possible association between cervical cancer and p73 G4C14-to-A4T14 in exon 2 and p53 Arg72Pro polymorphisms, an incident case-control study was conducted in Japanese. The cases were 112 cervical cancer patients. Controls were 320 healthy women and 122 non-cancer female outpatients. Risk estimation for each genotype by an unconditional logistic model demonstrated a possible association between the p73 A4T14 variant and the risk of cervical cancer in our Japanese population (OR = 1.57; 95%CI, 0.99-2.48, P = 0.053). There was no significant difference in the p53 Arg72Pro genotype frequency between the controls and cases. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：55 / 60

页数：6

共 42 条

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