Do corticosteroids damage the brain?

被引：283

作者：

Herbert, J

Goodyer, IM

Grossman, AB

Hastings, MH

de Kloet, ER

Lightman, SL

Lupien, SJ

Roozendaal, B

Seckl, JR

机构：

[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 2PY, England

[2] Univ Cambridge, Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England

[3] Univ Cambridge, Dept Psychiat, Cambridge CB2 2PY, England

[4] St Bartholomews Hosp, Dept Endocrinol, London, England

[5] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[6] Leiden Univ, Med Ctr, Leiden Amsterdam Ctr Drug Res, Dept Med Pharmacol, Leiden, Netherlands

[7] Univ Bristol, Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol, Avon, England

[8] McGill Univ, Douglas Hosp, Dept Psychiat, Ctr Human Studies Stress, Verdun, PQ H4H 1R3, Canada

[9] Univ Calif Irvine, Ctr Neurobiol & Learning & Memory, Irvine, CA 92717 USA

[10] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92717 USA

[11] Univ Edinburgh, Endocrinol Unit, Queens Med Res Inst, Edinburgh, Midlothian, Scotland

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 2006年 / 18卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

corticoids; brain damage; memory; hippocampus; rhythms; amygdala; Cushing's syndrome;

D O I：

10.1111/j.1365-2826.2006.01429.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Corticosteroids are an essential component of the body's homeostatic system. In common with other such systems, this implies that corticosteroid levels in blood and, more importantly, in the tissues remain within an optimal range. It also implies that this range may vary according to circumstance. Lack of corticosteroids, such as untreated Addison's disease, can be fatal in humans. In this review, we are principally concerned with excess or disturbed patterns of circulating corticosteroids in the longer or shorter term, and the effects they have on the brain.

引用

页码：393 / 411

页数：19

共 203 条

[1] Are subordinates always stressed? A comparative analysis of rank differences in cortisol levels among primates [J].