Factors Affecting the Absorption, Metabolism, and Excretion of Cocoa Flavanols in Humans

被引：30

作者：

Cifuentes-Gomez, Tania ^{[1
]}

Rodriguez-Mateos, Ana ^{[2
]}

Gonzalez-Salvador, Isidro ^{[1
]}

Alanon, Maria Elena ^{[1
]}

Spencer, Jeremy P. E. ^{[1
]}

机构：

[1] Univ Reading, Sch Chem Food & Pharm, Mol Nutr Grp, Reading RG2 6AP, Berks, England

[2] Univ Dusseldorf, Fac Med, Div Cardiol Pulmonol & Vasc Med, D-40225 Dusseldorf, Germany

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2015年 / 63卷 / 35期

基金：

英国生物技术与生命科学研究理事会;

关键词：

absorption; cocoa flavanols; (-)-epicatechin; excretion; metabolism; pharmacokinetics; CATECHOL-O-METHYLTRANSFERASE; (-)-EPICATECHIN METABOLITES; URINARY-EXCRETION; VASCULAR FUNCTION; PHENOLIC-ACIDS; ANTIOXIDANT CAPACITY; DIETARY FLAVONOIDS; DARK CHOCOLATE; BLOOD-PRESSURE; NITRIC-OXIDE;

D O I：

10.1021/acs.jafc.5b00443

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Cocoa is rich in a subclass of flavonoids known as flavanols, the cardiovascular health benefits of which have been extensively reported. The appearance of flavanol metabolites in the systemic circulation after flavanol-rich food consumption is likely to mediate the physiological effects on the vascular system, and these levels are influenced by numerous factors, including food matrix, processing, intake, age, gender, or genetic polymorphisms, among others. This review will focus on our current understanding of factors affecting the absorption, metabolism, and excretion of cocoa flavanols in humans. Second, it will identify gaps in these contributing factors that need to be addressed to conclusively translate our collective knowledge into the context of public health, dietary guidelines, and evidence-based dietary recommendations.

引用

页码：7615 / 7623

页数：9

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