Genetic toxicology: Findings and challenges

被引：4

作者：

Abilev, S. K. ^{[1
,2
]}

Glaser, V. M. ^{[2
]}

机构：

[1] Russian Acad Sci, Vavilov Inst Gen Genet, Moscow 119991, Russia

[2] Moscow MV Lomonosov State Univ, Dept Genet, Moscow 119899, Russia

来源：

RUSSIAN JOURNAL OF GENETICS | 2013年 / 49卷 / 01期

关键词：

SELECTION CPBS METHOD; MOUSE SPOT-TEST; TEST-SYSTEM; CARCINOGENICITY PREDICTION; MUTAGENIC ACTIVITY; RECOMMENDATIONS; BATTERY; TESTS; SPECIFICITY; INSTABILITY;

D O I：

10.1134/S102279541301002X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The review highlights the history of genetic toxicology as a distinct research area, as well as the issues of genetic toxicology and development of its methodology. The strategies and testing patterns of genotoxic compounds are discussed with the purpose of identifying potential human carcinogens, as well as compounds capable of inducing heritable mutations in humans. The main achievements of genetic toxicology in the 20th century are summarized and the challenges of the 21st century are discussed. DOI: 10.1134/S102279541301002X

引用

页码：70 / 80

页数：11

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