Anti-neuroinflammatory and NQO1 inducing activity of natural phytochemicals from Coreopsis tinctoria

被引：45

作者：

Li, Ning ^{[1
,2
]}

Meng, Dali ^{[1
,2
]}

Pan, Ying ^{[1
,2
]}

Cui, Qingling ^{[1
]}

Li, Guoxun ^{[4
]}

Ni, Hui ^{[3
]}

Sun, Yu ^{[3
]}

Qing, Degang ^{[3
]}

Jia, Xiaoguang ^{[3
]}

Pan, Yingni ^{[1
]}

Hou, Yue ^{[4
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 49, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

[3] XinJiang Inst Chinese Mat Med & Ethnodrug, Urumqi 830002, Peoples R China

[4] Northeastern Univ, Coll Life & Hlth Sci, Shenyang 110004, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2015年 / 17卷

基金：

中国国家自然科学基金;

关键词：

Coreopsis tinctoria Nutt; Anti-neuroinflammatory activities; NQO1 inducing activity; Effective phytochemicals; Neurodegenerative diseases; OXIDATIVE STRESS; NEURODEGENERATIVE DISEASES; THERAPEUTIC AGENTS; BIDENS-PILOSA; FLAVONOIDS; ANTIOXIDANT; L; IDENTIFICATION; CONSTITUENTS; GLUCOSIDES;

D O I：

10.1016/j.jff.2015.06.027

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Oxidative stress and neuroinflammation are critical in the pathogenesis of neurodegenerative diseases. Extract of Coreopsis tinctoria Nutt. has been shown to ameliorate neurodegenerative diseases, potentially via inducing quinone oxidoreductase 1 (NQO1) and anti-neuroinflammation. The present study aimed to characterize the chemical profile and bioactive composition of the extract to identify the effective components responsible for the effects. Chromatography and spectra analysis yielded 26 constituents, including a new chalcone (compound 8). Bioassays showed that compounds 6, 9, 15, 17, 19, 21 and 22 significantly inhibited production of nitric oxide (NO) in N9 cells induced by lipopolysaccharides (LPS). Meanwhile compounds 1, 3, 6, 11, 19 and 20 exhibited significant NQO1 inducing activities in Hepa 1c1c7 cells. These results suggest that extract of C. tinctoria Nutt. contains bioactive components attenuating the progress of neurodegenerative diseases, thus, a valuable functional food for the prevention of neurodegenerative diseases. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：837 / 846

页数：10

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