Can Molecular Methods Detect 1% Isoniazid Resistance in Mycobacterium tuberculosis?

被引：51

作者：

Folkvardsen, Dorte Bek ^{[1
]}

Svensson, Erik ^{[1
]}

Thomsen, Vibeke O. ^{[1
]}

Rasmussen, Erik Michael ^{[1
]}

Bang, Didi ^{[1
]}

Werngren, Jim ^{[2
]}

Hoffner, Sven ^{[2
]}

Hillemann, Doris ^{[3
]}

Rigouts, Leen ^{[4
]}

机构：

[1] Statens Serum Inst, Int Reference Lab Mycobacteriol, DK-2300 Copenhagen, Denmark

[2] Swedish Inst Communicable Dis Control, Solna, Sweden

[3] Forschungszentrum Borstel, Natl Reference Ctr Mycobacteria, Borstel, Germany

[4] Inst Trop Med, Mycobacteriol Unit, B-2000 Antwerp, Belgium

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2013年 / 51卷 / 05期

关键词：

DRUG SENSITIVITY; SPECIMENS;

D O I：

10.1128/JCM.00472-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Patients may harbor both drug-susceptible and -resistant bacteria, representing heteroresistance. We studied mixtures of isoniazid-resistant and -susceptible Mycobacterium tuberculosis strains. Conventional drug susceptibility testing was the most sensitive method of detection, whereas the line probe assay and sequencing were not able to detect the clinically relevant 1% proportion of resistant bacteria.

引用

页码：1596 / 1599

页数：4

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