The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning

被引：183

作者：

Xu, Xiuling ^{[4
]}

Chen, Xuesi

Ma, Ping'an ^{[2
]}

Wang, Xinri ^{[3
]}

Jing, Xiabin ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

[2] NE Normal Univ, Sch Life Sci, Changchun, Peoples R China

[3] Jilin Univ, Minist Educ, Key Lab Zoonosis, Changchun 130023, Peoples R China

[4] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2008年 / 70卷 / 01期

基金：

中国国家自然科学基金;

关键词：

emulsion; electrospinning; nanofiber; drug delivery; diffusion;

D O I：

10.1016/j.ejpb.2008.03.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The release behavior of a water-soluble small molecule drug from the drug-loaded nanofibers prepared by emulsion-electrospinning was investigated. Doxorubicin hydrochloride (Dox), a water-soluble anticancer agent, was used as the model drug. The laser scanning confocal microscopic images indicated that the drug was well incorporated into amphiphilic poly(ethylene glycol)-poly(L-lactic acid) (PEG-PLA) diblock copolymer nanofibers, forming "core-sheath" structured drug-loaded nanofibers. The drug release behavior of this drug-loaded system showed a three-stage diffusion-controlled mechanism, in which the release rate of the first stage was slower than that of the second stage, but both obeyed Fick's second law. Based on these results, it is concluded that the Dox-loaded fibers prepared by emulsion-electrospinning represent a reservoir-type delivery system in which the Dox release rate decreases with the increasing Dox content in the fibers. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：165 / 170

页数：6

共 25 条

[1] Biodegradable amphiphilic multiblock copolymers and their implications for biomedical applications [J].

Bae, YH ;

Huh, KM ;

Kim, Y ;

Park, KH .

JOURNAL OF CONTROLLED RELEASE, 2000, 64 (1-3) :3-13

[2]

Brannon-Peppas L., 1997, MED PLAST BIOMATER, V4, P34

[3] Advanced and controlled drug delivery systems in clinical disease management [J].

Brouwers, JRBJ .

PHARMACY WORLD & SCIENCE, 1996, 18 (05) :153-162

[4] Controlled release of ionic compounds from poly (L-lactide) microspheres produced by precipitation with a compressed antisolvent [J].

Falk, R ;

Randolph, TW ;

Meyer, JD ;

Kelly, RM ;

Manning, MC .

JOURNAL OF CONTROLLED RELEASE, 1997, 44 (01) :77-85

[5] Polymer microspheres for controlled drug release [J].

Freiberg, S ;

Zhu, X .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2004, 282 (1-2) :1-18

[6] MECHANISM OF SUSTAINED-ACTION MEDICATION - THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES [J].

HIGUCHI, T .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1963, 52 (12) :1145-&

[7] Preparation of poly-lactic acid microspheres containing the angiogenesis inhibitor TNP-470 with medium-chain triglyceride and the in vitro evaluation of release profiles [J].

Kakinoki, S ;

Yasuda, C ;

Kaetsu, I ;

Uchida, K ;

Yukutake, K ;

Nakayama, M ;

Fujiie, S ;

Kuroda, D ;

Kato, M ;

Ohyanagi, H .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2003, 55 (02) :155-160

[8] Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend [J].

Kenawy, ER ;

Bowlin, GL ;

Mansfield, K ;

Layman, J ;

Simpson, DG ;

Sanders, EH ;

Wnek, GE .

JOURNAL OF CONTROLLED RELEASE, 2002, 81 (1-2) :57-64

[9] Advances in biomaterials, drug delivery, and bionanotechnology [J].

Langer, R ;

Peppas, NA .

AICHE JOURNAL, 2003, 49 (12) :2990-3006

[10]

Langer R, 1998, NATURE, V392, P5

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