Cancer Antigen 125 (CA125), Human Epididymis Protein 4 (HE4), Risk of Malignancy Index (RMI), and Risk of Ovarian Malignancy Algorithm (ROMA) as Diagnostic Tests in Ovarian Cancer

被引:4
作者
Bouzari, Zinatossadat [1 ]
Rahimi, Hadiseh [2 ]
Gholinia, Hemmat [3 ]
Yazdani, Shahla [4 ]
Hajian-Tilaki, Karimollah [5 ]
Soleimani, Mohammad Jafar [6 ]
机构
[1] Babol Univ Med Sci, Infertil & Reprod Hlth Res Ctr, Hlth Res Inst, Babol Sar, Iran
[2] Babol Univ Med Sci, Babol Sar, Iran
[3] Babol Univ Med Sci, Clin Res Dev Unit, Hlth Res Ctr, Rouhani Hosp, Babol Sar, Iran
[4] Babol Univ Med Sci, Canc Res Ctr, Hlth Res Inst, Babol Sar, Iran
[5] Babol Univ Med Sci, Dept Biostat & Epidemiol, Babol Sar, Iran
[6] Babol Univ Med Sci, Infect Dis Res Ctr, Babol Sar, Iran
关键词
CA125; HE4; RMI; ROMA; Ovarian Cancer; Tumor Markers; CA-125; ULTRASOUND; MULTIPLE; TOOLS; WOMEN;
D O I
10.5812/ijcm.59395
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Distinguishing between malignant and benign ovarian masses is necessary to refer patients to centers with experience in the surgical. Objectives: The aim of this study was to analyze the diagnostic value of the tumor markers, including risk of malignancy index (RMI), human epididymis protein 4 (HE4), cancer antigen125 (CA125), and risk of ovarian malignancy algorithm (ROMA) in ovarian mass. Methods: One hundred patients with ovarian masses were assessed for the tumor markers ROMA, HE4, RMI, and CA125. The sensitivity and specificity of each parameter were calculated, using receiver-operating characteristic curves (ROCS) according to the area under the curve (AUC) for each method. Results: The median CA125, HE4, RMI, and ROMA serum levels had significant difference between malignant and benign masses in the overall assessment (P < 0.001). The AUCs were 0.83 (CA125), 0.88 (HE4), 0.85 (RMI), and 0.92 (ROMA) for benign vs. malignant masses in all the patients. The comparison of ROC curves was carried out, using a pairwise comparison method, and no differences were found among 4 methods. Conclusions: The results based on the AUC markers of CA125, HE4, RMI, and ROMA revealed that the accuracy trend of ROMA was higher than that of CA125, HE4, and RMI in all the patients and each group of pre- and post-menopausal patients.
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页数:7
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