The influence of modifiable cardiovascular risk factors on cognition, functioning, and inflammatory markers in first-episode psychosis: Results from a 2-year follow-up study

被引：2

作者：

Pujol, Nuria ^{[1
,2
,3
]}

Berge, Daniel ^{[1
,2
,3
]}

Mane, Anna ^{[1
,2
,3
]}

Bioque, Miquel ^{[3
,4
]}

Mezquida, Gisela ^{[3
,4
]}

Amoretti, Silvia ^{[3
,4
]}

Baeza, Inmaculada ^{[3
,4
,5
,11
]}

Gonzalez-Pinto, Ana ^{[3
,6
]}

Lobo, Antonio ^{[3
,7
]}

Cuesta, Manuel J. ^{[3
,8
,9
]}

Ribeiro, Maria ^{[3
,8
,9
]}

Sanchez-Tomico, Georgina ^{[1
,2
]}

Perez-Sola, V. ^{[1
,2
,3
]}

Verdolini, Norma ^{[3
,10
]}

Vieta, Eduard ^{[3
,5
,10
]}

Parellada, Mara ^{[3
,12
]}

Roldan, Alexandra ^{[3
,13
]}

Bernardo, Miquel ^{[3
,4
,5
]}

机构：

[1] Inst Neuropsychiat & Addict Barcelona MAR Hlth Pk, Passeig Maritim Barceloneta 25-29, Barcelona 08003, Spain

[2] Hosp Mar Med Res Inst IMIM, Barcelona, Spain

[3] Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain

[4] Hosp Clin Barcelona, Neurosci Inst, August Pi Sunyer Biomed Res Inst IDIBAPS, Barcelona Clin Schizophrenia Unit, Barcelona, Spain

[5] Univ Barcelona, Barcelona, Spain

[6] Hosp Santiago, Dept Psychiat, OSI Araba, Vitoria, Spain

[7] Hosp Univ Miguel Servet, Dept Family Med, Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain

[8] Complejo Hosp Navarra, Dept Psychiat, Navarra, Spain

[9] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain

[10] Hosp Clin Barcelona, Inst Neurosci, Bipolar Disorder Unit, Barcelona, Spain

[11] Hosp Clin Barcelona, Inst Neurosci, Child & Adolescent Psychiat & Psychol Dept, Barcelona, Spain

[12] Univ Complutense, Hosp Gen Univ Gregorio Maranon, Child & Adolescent Psychiat Dept, Sch Med,IiSGM, Madrid, Spain

[13] Sant Pau Hosp, Psychiat Dept, Barcelona, Spain

来源：

PSYCHIATRY RESEARCH | 2022年 / 316卷

关键词：

First-episode psychosis; Cognition; Cardiovascular risk factors; Lymphocyte; 1ST EPISODE PSYCHOSIS; COMPLETE BLOOD-COUNT; METABOLIC ABNORMALITIES; PREMORBID ADJUSTMENT; BIPOLAR DISORDER; DRUG-NAIVE; SCHIZOPHRENIA; IMPAIRMENT; METAANALYSIS; MIDLIFE;

D O I：

10.1016/j.psychres.2022.114760

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

To explore the influence of cardiovascular risk factors (CVRFs) on cognitive symptoms, functional impairment, and systemic inflammatory markers in first-episode psychosis (FEP) patients at baseline and 2-year follow-up. Method: In a sample of 70 FEP patients and 85 age-and sex-matched healthy controls, we assessed nine modifiable CVRFs. All participants were classified into two subgroups according to their CVRF profile: lower (0-1 CVRFs) or higher (>= 2 CVRFs). The following outcomes were measured at baseline and 2-year follow-up: cognition; functional outcomes; and white blood cell (WBC) subtype. Adjusted general linear models were conducted to study the effect of diagnosis and CVRF profile on cognition, functioning, WBC, and longitudinal changes in these variables. At baseline, FEP patients with a higher CVRF profile showed a significantly slower performance on the TMT-A test for psychomotor speed and higher lymphocyte levels than patients with a lower CVRF profile. No longitudinal changes were observed in primary outcomes at 2-year follow-up. Among FEP patients with a higher CVRF profile, slower psychomotor speed performance did not correlate with increased lymphocyte levels. Our findings suggest that the cognitive effects of CVRFs manifest early in the course of psychosis, thus highlighting the importance of targeting both CVRFs and cognitive deficits in FEP.

引用

页数：11

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