Solvent-Free Tandem Synthesis of 2-Thiazolines and 2-Oxazolines Catalyzed by a Copper Catalyst

被引：41
作者：
Li, Xiangnan [1 ,2 ]
Zhou, Baoyue [1 ,2 ]
Zhang, Jin [1 ,2 ]
She, Mengyao [1 ,2 ]
An, Shujuan [1 ,2 ]
Ge, Haixia [1 ,2 ]
Li, Cong [1 ,2 ]
Yin, Bing [1 ,2 ]
Li, Jianli [1 ,2 ]
Shi, Zhen [1 ,2 ]
机构：
[1] NW Univ Xian, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Shaanxi, Peoples R China
[2] NW Univ Xian, Coll Chem & Mat Sci, Xian 710069, Shaanxi, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 08期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Heterocycles; Copper; Nitriles; Tandem reactions; OXAZOLINES; THIAZOLINES; CYCLODEHYDRATION; LIGANDS; CYCLOADDITION; INHIBITORS; ALCOHOLS; DESIGN; POTENT; ACIDS;
D O I：
10.1002/ejoc.201101786
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Tandem reactions of nitriles with 2-aminoethanethiol hydrochloride or amino alcohols in the presence of a catalytic amount of cupric methacrylate ((Cu2L4)-L-II, L = methacrylate) were employed to prepare 2-thiazolines and 2-oxazolines under mild reaction conditions. The synthetic procedure showed high selectivity for the synthesis of mono- and bis-thiazolines and oxazolines, and a variety of 2-thiazolines and 2-oxazolines was obtained in good to excellent yields.
引用
收藏
页码：1626 / 1632
页数：7
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