Bioactive 3,4-seco-Triterpenoids from the Fruits of Acanthopanax sessiliflorus

被引：37

作者：

Lee, Dae-Young ^{[1
,2
]}

Seo, Kyeong-Hwa ^{[1
,2
]}

Lee, Dong-Sung ^{[3
]}

Kim, Youn-Chul ^{[3
]}

Chung, In-Sik ^{[1
,2
]}

Kim, Gye-Won ^{[4
]}

Cheoi, Dae-Sung ^{[5
]}

Baek, Nam-In ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Grad Sch Biotechnol, Yongin 446701, South Korea

[2] Kyung Hee Univ, Dept Oriental Med Mat & Proc, Yongin 446701, South Korea

[3] Wonkwang Univ, Coll Pharm, Standardized Mat Bank New Bot Drugs, Iksan 570749, South Korea

[4] Hankyung Natl Univ, Brewing Res Ctr, Ansung 456749, South Korea

[5] Jeongseon Agr Extens Ctr, Jeongseon 233852, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 06期

关键词：

TRITERPENOID SAPONINS; PANCREATIC LIPASE; GLYCOSYL ESTERS; SENTICOSUS; LEAVES; DIVARICATUS;

D O I：

10.1021/np3002173

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new 3,4-seco-lupane triterpenes and glycosides, acanthosessiligenins I and II (1, 3) and acanthosessiliosides A-F (2, 4-8), as well as six known 3,4-seco-lupane triterpenes (9-14) were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures of 1-8 were determined by spectroscopic data interpretation. All isolated compounds were tested for their cytotoxicity against six human cancer cell lines and their ability to inhibit LPS-induced nitric oxide production in RAW 264.7 macrophages.

引用

页码：1138 / 1144

页数：7

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