G protein-coupled receptor kinases: Past, present and future

被引：131

作者：

Komolov, Konstantin E. ^{[1
]}

Benovic, Jeffrey L. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Biochem & Mol Biol, Philadelphia, PA 19107 USA

来源：

CELLULAR SIGNALLING | 2017年 / 41卷

基金：

美国国家卫生研究院;

关键词：

Arrestins; GPCR; GRK; Phosphorylation; Signaling; X-ray crystallography; BETA-ADRENERGIC-RECEPTOR; ERYTHROCYTE ADENYLATE-CYCLASE; PHOSPHORYLATION-INDEPENDENT REGULATION; CATECHOLAMINE-INDUCED DESENSITIZATION; LIGHT-DEPENDENT PHOSPHORYLATION; N-TERMINAL REGION; RHODOPSIN KINASE; BETA(2)-ADRENERGIC RECEPTOR; CRYSTAL-STRUCTURE; ALPHA(2A)-ADRENERGIC RECEPTOR;

D O I：

10.1016/j.cellsig.2017.07.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review is provided in recognition of the extensive contributions of Dr. Robert J. Lefkowitz to the G protein coupled receptor (GPCR) field and to celebrate his 75th birthday. Since one of the authors trained with Bob in the 80s, we provide a history of work done in the Lefkowitz lab during the 80s that focused on dissecting the mechanisms that regulate GPCR signaling, with a particular emphasis on the GPCR kinases (GRKs). In addition, we highlight structure/function characteristics of GRK interaction with GPCRs as well as a review of two recent reports that provide a molecular model for GRK-GPCR interaction. Finally, we offer our perspective on some future studies that we believe will drive this field.

引用

页码：17 / 24

页数：8

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