Cortical spreading depression in migraine-time to reconsider?

被引：3
作者：
McComas, Alan J. [1 ]
Upton, Adrian R. M. [1 ]
机构：
[1] McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada
来源：
ARQUIVOS DE NEURO-PSIQUIATRIA | 2015年 / 73卷 / 08期
关键词：
migraine; spreading depression; transcranial magnetic stimulation; TRANSCRANIAL MAGNETIC STIMULATION; CEREBRAL-CORTEX; GAMMA-OSCILLATIONS; INHIBITORY PROCESS; FUNCTIONAL MRI; AURA; PATHOPHYSIOLOGY; HEADACHE; BRAIN; SCOTOMAS;
D O I：
10.1590/0004-282X20150094
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
New evidence concerning the pathophysiology of migraine has come from the results of therapeutic transcranial magnetic stimulation (tTMS). The instantaneous responses to single pulses applied during the aura or headache phase, together with a number of other observations, make it unlikely that cortical spreading depression is involved in migraine. tTMS is considered to act by abolishing abnormal impulse activity in cortical pyramidal neurons and a suggestion is made as to how this activity could arise.
引用
收藏
页码：714 / 721
页数：8
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