Delusional ideation, manic symptomatology and working memory in a cohort at clinical high-risk for psychosis: A longitudinal study

被引:21
作者
Broome, M. R. [1 ,2 ]
Day, F. [1 ]
Valli, I. [1 ]
Valmaggia, L. [1 ]
Johns, L. C. [1 ]
Howes, O. [1 ]
Garety, P. [3 ]
McGuire, P. K. [1 ]
机构
[1] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London WC2R 2LS, England
[2] Univ Warwick, Warwick Med Sch, Hlth Sci Res Inst, Coventry CV4 7AL, W Midlands, England
[3] Kings Coll London, Inst Psychiat, Dept Psychol, London SE5 8AF, England
关键词
Delusions; Prodromal; Memory; Mania; Psychosis; High-risk; ULTRA-HIGH RISK; SCHIZOPHRENIC-PATIENTS; PREFRONTAL CORTEX; TWINS DISCORDANT; RATING-SCALE; 1ST EPISODE; PEOPLE; BRAIN; DISORDER; SALIENCE;
D O I
10.1016/j.eurpsy.2010.07.008
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
We followed up a cohort (n = 35) of clients with an "At Risk Mental State" (ARMS) for almost 2 years (mean 21.3 months). At baseline, these clients had taken part in research looking at the relationship between reasoning biases, memory, personality styles and delusional ideation. During the follow-up period, clients underwent a package of intervention from a specialist early detection team. Eighty percent (n = 28) of these clients were successfully re-interviewed. There was improvement across the cohort as a whole, however five participants (17.9%) had made the transition to psychosis at follow-up. Those who had become psychotic had lower levels of manic symptomatology at baseline than those who did not enter the first episode. Further, across the cohort, impaired working memory and delusional ideation at baseline combined to predict 45% of the delusional ideation at follow-up. These preliminary findings suggest that working memory impairments may be linked to the persistence of delusional ideation and that manic symptoms in someone with an ARMS may suggest that such an individual is less likely to develop a frank psychotic episode. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:258 / 263
页数:6
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