Industrial natural product chemistry for drug discovery and development

被引：180
作者：
Bauer, Armin [1 ]
Broenstrupt, Mark [1 ]
机构：
[1] Sanofi Aventis Deutschland GmbH, R&D LGCR Chem, D-65926 Frankfurt, Germany
来源：
NATURAL PRODUCT REPORTS | 2014年 / 31卷 / 01期
关键词：
GLUCOSE COTRANSPORTER 2; GLUCAGON-LIKE PEPTIDE-1; ALA-D-ALA; AFFINITY NA+/GLUCOSE COTRANSPORTER; ANTITUMOR POLYETHER MACROLIDE; ANTIFUNGAL AGENT CILOFUNGIN; RELAPSED HODGKIN LYMPHOMA; IMPROVES GLYCEMIC CONTROL; GLP-1 RECEPTOR AGONISTS; HALICHONDRIN-B ANALOG;
D O I：
10.1039/c3np70058e
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In addition to their prominent role in basic biological and chemical research, natural products are a rich source of commercial products for the pharmaceutical and other industries. Industrial natural product chemistry is of fundamental importance for successful product development, as the vast majority (ca. 80%) of commercial drugs derived from natural products require synthetic efforts, either to enable economical access to bulk material, and/or to optimize drug properties through structural modifications. This review aims to illustrate issues on the pathway from lead to product, and how they have been successfully addressed by modern natural product chemistry. It is focused on natural products of current relevance that are, or are intended to be, used as pharmaceuticals.
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页码：35 / 60
页数：26
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