Antiviral Activities of Interleukin-27: A Partner for Interferons?

被引：23

作者：

Amsden, Heather ^{[1
]}

Kourko, Olena ^{[1
]}

Roth, Madison ^{[1
]}

Gee, Katrina ^{[1
]}

机构：

[1] Queens Univ, Dept Biomed & Mol Sci, Kingston, ON, Canada

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

interleukin-27; interferons; virus; viral immunology; infection; antiviral immunity; INNATE IMMUNE-RESPONSE; T-CELL RESPONSES; NF-KAPPA-B; HUMAN MACROPHAGES; IL-10; PRODUCTION; HIV-1; INFECTION; DENDRITIC CELLS; VIRUS-INFECTION; HUMAN MONOCYTES; PROTEIN-KINASE;

D O I：

10.3389/fimmu.2022.902853

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Emergence of new, pandemic-level viral threats has brought to the forefront the importance of viral immunology and continued improvement of antiviral therapies. Interleukin-27 (IL-27) is a pleiotropic cytokine that regulates both innate and adaptive immune responses. Accumulating evidence has revealed potent antiviral activities of IL-27 against numerous viruses, including HIV, influenza, HBV and more. IL-27 contributes to the immune response against viruses indirectly by increasing production of interferons (IFNs) which have various antiviral effects. Additionally, IL-27 can directly interfere with viral infection both by acting similarly to an IFN itself and by modulating the differentiation and function of various immune cells. This review discusses the IFN-dependent and IFN-independent antiviral mechanisms of IL-27 and highlights the potential of IL-27 as a therapeutic cytokine for viral infection.

引用

页数：11

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