Constitutive Antiviral Immunity at the Expense of Autoimmunity

被引：7

作者：

Todd, John A. ^{[1
]}

机构：

[1] Univ Cambridge, JDRF Wellcome Trust Diabet & Inflammat Lab, NIHR Biomed Res Ctr, Dept Med Genet,Cambridge Inst Med Res, Cambridge CB2 0XY, England

来源：

IMMUNITY | 2014年 / 40卷 / 02期

基金：

英国惠康基金;

关键词：

IFIH1;

D O I：

10.1016/j.immuni.2014.01.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this issue of Immunity, Funabiki et al. (2014) have identified in mice a mutation of the IFIH1 gene, encoding the viral receptor MDA5 that causes constitutive IFN production and fatal autoimmune disease. The authors show that the autoimmune disease-associated variant of human MDA5 is permanently switched on.

引用

页码：167 / 169

页数：3

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