Sexual development in prepubertal obese boys: a 4-year longitudinal study

被引：7

作者：

Zhai, Lingling ^{[1
]}

Zhao, Jian ^{[2
]}

Bai, Yinglong ^{[1
]}

Liu, Li ^{[1
]}

Zheng, Linlin ^{[3
]}

Jia, Lihong ^{[1
]}

Yao, Xingjia ^{[1
]}

机构：

[1] China Med Univ, Coll Publ Hlth, Dept Child & Adolescent Hlth, Shenyang 110001, Liaoning Provin, Peoples R China

[2] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang, Liaoning Provin, Peoples R China

[3] Eastern Liaoning Univ, Coll Med, Dandong, Liaoning Provin, Peoples R China

来源：

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2013年 / 26卷 / 9-10期

基金：

中国国家自然科学基金;

关键词：

longitudinal study; obesity; sex hormones; sex organs; testicular volume; HUMAN ADIPOSE-TISSUE; SALIVARY TESTOSTERONE; CHILDHOOD OBESITY; PUBERTAL GROWTH; BODY-FAT; OVERWEIGHT; HEALTH; WORLDWIDE; CHILDREN; GENDER;

D O I：

10.1515/jpem-2012-0398

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of the study was to evaluate whether or not sexual development differs between boys with prepubertal obesity and boys of normal weight. We enrolled healthy obese and normoweight schoolboys from Shenyang City, Liaoning, China. Eligible boys were at Tanner stage 1 and 8 years of age at baseline. We measured testosterone and estradiol concentrations in the saliva and assessed auxology annually for 4 years. In all 56 obese and 56 normoweight boys, the height, weight, body composition, and sex organ volume increased with age. The percentages of body fat, fat mass, and lean mass were all higher in obese than in normoweight boys. The mean testicular volume was smaller in obese boys than in normoweight boys. The sex hormone concentrations increased with age, except for testosterone in obese boys in year 3 of follow-up. In year 4, estradiol concentrations were significantly higher in obese boys than in normoweight boys. Excessive adiposity in prepubertal boys might affect testicular volume, possibly because of high estradiol and low testosterone concentrations.

引用

页码：895 / 901

页数：7

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